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The science of microvascular disease
Recent studies show that a substantial number of patients with suspected coronary artery disease examined by coronary angiography have apparently normal arteries, suggesting they suffer from microvascular disease. Such pathologies can be attributed to spasm, coagulation, micro-obstruction by leucocytes, adverse microvascular remodelling, and endothelial dysfunction among other potential mechanisms.
Although there has been an increase in clinical papers addressing the coronary microcirculation, says Pries, the amount of basic science research has declined over the past few decades. ‘What’s needed,’ he adds, ‘is a greater understanding before we can move on to develop treatments.’…..
